How does nucleotide-excision repair differ from base-excision repair?
Nucleotide-excision repair reverses the chemical reaction that caused the lesion, whereas base-excision repair removes thedamaged bases and replaces them with normal ones.
Only the base isremoved in base-excision repair, whereas the entire nucleotide isremoved in nucleotide-excision repair.
Base-excisionrepair requires no protein components and can occur by simpleabsorption of UV light, whereas nucleotide-excision repair requires several enzymes.
Base-excisionrepair recognizes and removes single damaged bases, whereasnucleotide-excision repair is more general, recognizing many different kinds of lesions that distort the DNA molecule.