How does aggregation occur in sickle-cell anemia? Place the steps in the correct order from no aggregation to sickle red blood cell. Note that deoxyhemoglobin is generally in the T state; oxyhemoglobin is in the R state.
Additional T state HbS interact with the growing aggregation to form an insoluble fiber.
Val interacts with the "pocket" of a beta chain on another HbS.
R state Hb shifts to T state Hb
O2 decreases due to vigorous exercise or high altitude.