How do metastases cause death


Problem:

Metastasis to the liver and lungs are the main causes of death in colorectal cancer.(1) I understand that colorectal cancer may have metastases.

But how do these metastases cause death? Please explain.

Reference

(1) A. Bolocan, D. Ion, D.N. Ciocan, D.N Paduraru. Chirurgia (2012) 107:555-563. Introduction.

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Biology: How do metastases cause death
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