Problem:
The pedigree below shows the transmission of albinism (absence of skin pigment) in a human family.
Black color represents albinism and white color represents normal pigmentation.
- mode of transmission of albinism is autosomal recessive
- genotypes of males and females in generation 1 is Aa
The female I-1 and her mate, male I-2, had four children, one of whom has albinism.
Required:
Question 1: What is the probability that they could have had a total of four children with any other outcome except one child with albinism and three with normal pigmentation?
Question 2: What is the probability that any of the other four children are carriers of the allele for albinism? Show your work.