How can you determine binding affinity of protein for dna


Problem:

Question 1: If you were provided with a purified possible histone protein (from a bacterium), how would you establish if it is a DNA-binding protein?

Question 2: Assume that the protein binds DNA. How can you assess whether it is a site-specific or non-specific DNA-binding protein?

Question 3: How can you determine the binding affinity of the protein for the DNA?

I dont need long explanation. Just few sentences of expanation.

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Biology: How can you determine binding affinity of protein for dna
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