Assignment task: Chronic kidney disease (CKD) is accompanied by hyperphosphatemia, hypocalcemia, impaired activation of vitamin D, hyperparathyroidism, and skeletal complications.
Tasks:
Please address the following:
Q1. Explain the impaired activation of vitamin D and its consequences on calcium and phosphate homeostasis, parathyroid function, and mineralization of the bone in people with CKD.
Q2. Explain the possible complications of the administration of activated forms of vitamin D on parathyroid function and calcium and phosphate homeostasis (e.g., calcium × phosphate product).