Problem 1: Draw the life cycle of Leishmania amazonensis, with numbers for each step, and then use short sentences to describe the most important stages. This diagram should be your own work; you will not gain any marks for a diagram that is simply copied and pasted from the Internet, We do not expect your diagram to be a piece of high-quality art; a simple block diagram, or something that is hand-drawn and then scanned, is fine. (Hint: one way to adapt a figure is to combine several pieces of information into a single new depiction). If you adapt an existing figure, then you must cite where the original image(s) came from, and include a screenshot of the original(s) at the end of your answer. In addition, search the Internet for a peer-reviewed article or review that provides additional details of how Leishmania parasites manage to remain in the sandfly midgut and then find their way to the mouthparts. few short notes about this and paste the abstract of the paper into your answer, including the title, authors and journal name/volume/pages.
Problem 2: Describe the various ways in which Leishmania amazonensis is adapted to life inside a human host.
This is what I have worked out for i. But I just dont know how to draw it up?
Diagram background: tropical rainforest environment needed for sandfly to live in. Host is vertebrae mammals such as humans, dogs and rats.
1. Uninfected sandfly feeds on blood of host with L. Amazonensis parasites in its blood. Parasites are intracellular amastigotes feeding on the amino and fatty acid proteins inside the blood cells.
2. Parasite amastigotes pass into sandfly's gut where there are no proteins to feed on. In a process lasting 5 days, the amastigotes transform into extracellular promastigotes so they can feed on the glucose present in the sandfly's gut.
3. Sandfly feeds again, converts it blood food into glucose so the promastigotes can now feed on the glucose, become infective and multiply.
4. Infective promastigotes migrate from sandfly's guts to it's probiscus.
5. Sandfly feeds on uninfected host, injecting infective promastigotes in host as part of feeding process.
6. Host's immune system responds to arrival of infective promastigotes in host's blood by sending phagocytes to enclose and destroy the promastigotes. However, the L. Amazonensis promastigotes cannot feed as there is no glucose in the host's blood so they corrupt the phagocytosis process and instead of being enclosed and destroyed by the host's phagocytes, the allow themselves to be enclosed and absorbed so they can convert into intracellular amastigotes that can feed on the amino and fatty acid proteins present inside cells.
7. As the amastigotes feed, they multiply and, in addition to remaining in the host's blood, they also migrate to susceptible parts of the host's body, For L. Amazonensis these are:i. the skin (cutaneous) ii. the mouth and nose (mucocutaneous) where they cause lesions and ulcers that can be necrotic.
8. The infective amastagotes are ingested by another feeding sandfly and the infection process starts again.
Please can you help me hand draw it and attach to here