Problem: In this case of pregnancy, nitrofurantoin 100 mg orally twice daily for 7 days is the preferred treatment. Nitrofurantoin is a urinary antiseptic that is well absorbed, concentrates in the urine, and is particularly effective against E. coli, the most common uropathogen (Kuperman & Koren, 2016). Fosfomycin, another pregnancy-safe option, may be considered in less symptomatic cases or when adherence is a concern, but nitrofurantoin remains more effective for symptomatic infections requiring multi-day coverage (ACOG, 2023). Need Assignment Help?