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Discussion about mutant allele for tay-sachs disease


Question: In a certain community, a mutant allele for Tay-Sachs disease is prevalent. This mutation removes a Hind III restriction site in the gene sequence. A probe is available for this region, with the following homology: The Tay-Sachs mutant region is represented by a Hind III restriction site at base pair #4 and another at base pair #18. The base pair sequence for a normal gene in this same region is represented by a Hind III restriction site at base pair #4, #10, and #19. The probe is 7 base pairs long. Two couples in this community are expecting children. Each couple has a DNA test to determine if their child will have Tay-Sachs. The results of the Southern blot, probed for the region described above, is shown below. M1 and F1 have two dashes (a top dash and a bottom dash), while Child 1 has only the top dash. M2, F2, and Child 2 all have the same two dashes that M1 and F1 have. Using these results, how would you counsel the couples? Need Assignment Help?

 

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Biology: Discussion about mutant allele for tay-sachs disease
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