Problem:
Please explain each question carefully with details to understand better the concept.
Question 1: Discuss the primary condition that stimulates a beta cell to secrete insulin as well as other possible potentiating factors (including the in cretin effect)
Question 2: Describe the primary intracellular condition that results in insulin release when beta cells metabolize glucose, AA, or FAs.
Question 3: Explain the sequence of events involving membrane channels that induces the release of insulin from beta cell secretary vesicles.
Please explain all the answers in detail.