Problem: In adult patients diagnosed with major depressive disorder (Population), what is the effect of pharmacogenomic-guided antidepressant prescribing combined with structured patient education and follow-up (Intervention), in comparison to standard prescribing practices without pharmacogenomic testing or structured follow-up (Comparison), on medication adherence and depression symptom improvement (Outcome), to be completed over six months (Time)? Identify components of your PICOT question where peer input would help refine those elements. Need Assignment Help?