Diabetes mellitm
This anabolic hormone exerts its action on key glycolytic enzymes thus leading to the conversion of glucose to pyruvate as explained under the regulation of glycolysis. On the other hand, insulin suppresses the action of all key gluconeogenic enzymes. With respect to glycogen metabolism, the excess glucose is converted to glycogen by activating glycogen synthase thus leading to glycogenesis and inhibiting glycogenolysis. In this metabolic disease-diabetes mellitus, the lack of insulin reverses these actions and the antagonistic hormones (like glucagon, epinephrine, catecholamines, thyroxine etc.) by their concerted efforts on various ~athwavs brine: about the hyperglycemic condition.