Determine the major pathway of glycine degradation


In order to determine the major pathway of glycine degradation, you devise an experiment in which mice are fed 13C(alpha)-labeled glycine, and the livers are then isolated and radioactive intermediates detected by GC-MS. Interestingly, you find that the amino acid serine contains the most radioactivity, and that both the Calpha and Cbeta carbons of the serine residue are labeled with 13C. Explain these observations.

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Biology: Determine the major pathway of glycine degradation
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