Question 1: Describe the role of macrophages in nonspeci?c defense and speci?c defense the ?rst time the mother is exposed to Rh+ antigens.
Question 2: If the blood type of the mother is known to be Rh-, and the father is Rh+, then there is a possibility that HDN will be an issue for this couple. In these cases the mother may be injected with Rh immune globulins, a protein that binds to Rh+ red blood cells, but displays an antigen that is unlike any of the other blood type antigens. Explain how giving the mother Rh immune globulins will prevent HDN in subsequent pregnancies.
Question 3: Should HDN be classi?ed as an "autoimmune" disorder? Explain your answer.