1. Describe the mechanisms of action, biochemical targets and effects of these lipid-lowering drugs; statins, niacin, fibrates, colestipol, torcetrapib, avasimibe, implitapide, praluent and ezetimibe?
2. What are SREBP and SCAP? What roles do they play in the cholesterol homeostasis?
3. A nonfunctional MTP gene/protein causes ABL.What are the possible effects on lipid levels and cardiovascular pathology if this protein is overexpressed?
4. Based on your understanding of the role of ABCA1 in the formation of HDL particles,how would you design a therapeutic modality to overcome a weakened interaction between ABCA1 and apoA-I that results from a mutation in ABCA1 gene?
How would you modulate the reverse cholesterol transport?