Define the Uremia and Nitrogen Disposal?
In animals, faecal and renal nitrogen were enhanced and decreased uremia was seen in normal and nephrectomised animals. The mechanisms proposed are:
- increased colonic biomass and consequent nitrogen fixation with acidification and conversion of diffusible ammonia into less diffusible ammonium ion,
- Due to NDO's osmotic effect, urea transfers into distal ileum and large intestine is accelerated. In the large intestine, ureolytic microflora may act. When fermentable carbohydrate intake is high, the amount of ammonia required may become insufficient and blood urea is used as a substrate, and
- Inhibition of ureagenesis in the liver by propionate.