Define Role of Glucocorticoids in controlling gene expression?
Glucocorticoids are another class of hormones involved in the regulation of lipogenic enzymes, but their role in nutritional regulation of these enzymes is not well understood. The glucocorticoids may be permissive for the expression of a variety of hepatic enzymes, involved in intermediary metabolism.
Changes in the levels of fuels derived directly or indirectly from dietary nutrients also regulate the activities of lipogenic enzymes. Thus, dietary fructose stimulates an increase in the activities of the lipogenic enzymes in starved rats, whether they are diabetic or not. Glucose is effective only in non-diabetic animals.