Define Foods Effect on Drug Transport?
Many drugs are transported in blood bound lo plasma proteins. Severe malnutrition or diseases affecting the synthesis of plasma proteins (such as liver disease) may reduce the body's ability to transport drugs and hence impair their effectiveness. Albumin is the most important drug-binding protein in the blood. Low serum albumin levels (due to inadequate protein intake and poor nutrition), therefore, provides fewer binding sites for some highly protein-bound drugs such as warfarin and anticonvulsant phenytoin, which may lead to risk of excessive anlicoagulation and bleeding or toxicity, respectively.