Define Effect of Deficiency of chromiumin humans?
Hallmark of marginal chromium deficiency is impaired glucose tolerance. Individuals receiving TPN without chromium have been shown to develop symptoms of deficiency such as impaired glucose tolerance with high blood glucose level and glucose excretion in urine. Peripheral neuropathy has also been reported which was reversed with chromium supplementation. Chromium deficiency results in insulin resistance characterized by hyperinsulinemia. Hyperinsulinemia is implicated as a risk factor for coronary heart disease.