consider the effects of local environment on the acidity of the following amino acid residues within a protein. in each case, state whether the side chain pka of the underlined residue will increase, decrease, or remain the same. then briefly state why.
a) the histidine (underlined) residue in deoxyhemoglobin that is positioned to form an ion pair with the nearby aspartate residue.
b) a lysine (underlined) residue when positioned near an arginine residue.
c) a glutamic acid (underlined) residue when positioned near a lysine residue