Q1. Describe the regulation of glycogen synthase and glycogen phosphorylase in the synthesis and degradation of glycogen in the liver and skeletal muscle.
Q2. Describe the mechanism by which epinephrine induces glycogenolysis in the skeletal muscle.
Q3. Compare and contrast glucokinase and hexokinase
Q4. List the cofactors required for the PDC and the order of their use within the enzyme .
Q5. Describe the roles and regulation of citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, and malate dehydrogenasein the TCA cycle
Q6. List the major reactions that replenish TCA cycle intermediates
Q7. Describe the role of the malate aspartate shuttle in moving cytosolic NADH into the mitochondria and transporting aspartate out of themitochondria
Q8. Describe the reaction and regulation of the pyruvate dehydrogenase complex (PDC) including its reactants, products and cellular localization.
Q9. List the enzymes of the TCA that require thiamine as a cofactor. List the cofactors required for the PDC and the order of their use within the enzyme
Q10. Describe the role of Complex II (succinate dehydrogenase) in the electron transport chain
Q11. Explain the effect of the ratio of NADH:NAD and ADP:ATP on the activity of the TCA cycle.
Q12. Describe the role of anaerobic glycolysis in the red blood cell
Q13. Relate the activity of glucose 6 phosphate dehydrogenase to levels of NADPH in the cell
Q14. Describe the reaction catalyzed Aldolase B in fructose metabolism
Q15. Describe the role of Aldolase B in fructose metabolism
Q16. Distinguish between hereditary fructose intolerance and essential fructosuria including the metabolic ramifications of each condition
Q17. Determine the fate of lactate generated by the red blood cell in the Cori cycle
Q18. Describe the requirement of NADPH in the red blood cells.
Q19. Describe the role of glutathione in the red blood cell.