Problem
Calculate which one of the below results in better sterilization. Assume saturated steam in both cases. Show calculations and explain the rationale. SIP of bioreactor done at 124 deg C for 15 min, takes about 20 min to heat up, and 60 min to cool down. SIP of bioreactor done at 111 deg C for 60 min, takes about 12 min to heat up and 35 min to cool down