Q1. Assign the words or abbreviations in the word bank to the appropriate definition below.
Q2. Draw a diagram of a typical IgG molecule. Label the following in your diagram: H chains, L chain, interchain disulfide bonds, Fab and Fc regions, variable and constant regions. Briefly describe five categories of effector functions associated with antibodies, and indicate which protion of the antibody molecule is involved in each category.
Q.3 Match each immunoglobulin isotype with the description(s) listed below that are true about that isotype. Some of the descriptions may apply to more than one isotype; others may not apply to any isotype.
Q.4Match each hypersensitivity type with the descriptions (s) (a-1) listed below that are true about that type of hypersensitivity reaction. Some of the descriptions may apply to more than one reaction type; others may not apply to any.
Q.5 Using simple drawings show the 2D tri-molecular interaction of TCR/Ag/MHC (one drawing for each class I and class II). Indicate the roles of CD8 and CD4, and the types of cells that are involved. In words, briefly describe differences between the types of peptides that bind to class I and class II MHC molecules. what are the origins and processing pathways of the peptides?
Q6. Tumor immunology concerns immune responses to cancer cells.
a) Distinguish between tumor specific and tumor-associated antigens and give one example of each.
b) Briefly describe three ways by which cancerous tumors evade the immune system.
c) Briefly describe two types of cancer immunotherapies in current use, or under development and give one example of each. Be sure to explain the mechanism of action for each type.
Q7. Autoimmune disease occurs when there is a breakdown in tolerance.
a) Briefly explain the difference between central and peripheral tolerance. Where do they take place? What cell types and mechanisms are involved?
b) Briefly describe one example of an autoimmune disease considered in this course. What tissue(s) are affected? What immune mechanisms underline the disease? What are the disease symptoms?
c) Describe two examples of therapeutic drug strategies that are in use for treatment of autoimmune disease. Be sure to mention the mechanisms of their actions.