Which of the following is true of the binding energy derived from enzyme-substrate interactions? A. Most of the binding energy is used to decrease the deltaG°' of the reaction. B. Most of the binding energy is derived from a covalent bond formation between the substrate and the enzyme. C. Most of the binding energy is used to decrease the affinity of the enzyme for the product. D. Binding energy is sometimes used to hold the substrate in an optimum orientation for the chemistry to occur. E. Binding energy contributes to the decrease in deltaG°'folding for solvent molecules surrounding the enzyme.