Question: What is a critical cardiovascular consequence of administering a nonsteroidal anti-inflammatory drug (NSAID) to a mother late in pregnancy? Need Assignment Help? This can result in increased maternal blood pressure and eclampsia. This can result in increased fetal oxygen demand and cardiac hypoxia. This can result in opening of the foramen ovale and creation of an atrial septal defect. This can result in premature closure of the ductus arteriosus and fetal hypoxia.