A) Definitive Infective Endocarditis
1) Pathological Criteria
• Micro organism: demonstrated by culture or histology in a vegetation; or in a vegetation that has embolized, or in an intra cardiac abcess, or
• Pathological lesions: vegetation or intracardiac abscess present, confirmed by histology showing active endocarditis.
2) Clinical Criteria, using specific definitions listed below:
• Two major criteria, or
• One major and three minor criteria, or
• Five minor criteria.
B) Possible Infective Endocarditis
• One major +1 minor or 3 minor.
C) Rejected
• Firm alternative diagnosis for manifestations of endocarditis, or
• Sustained resolution of manifestations of endocarditis, with antibiotic therapy for 4 days or less, or
• No pathological evidence of infective endocarditis at surgery or autopsy, after antibiotic therapy for 4 days or less.