1. Explore the role of the epigenome and/or other gene expression regulatory mechanisms in the development of cancer. Discuss in detail one possible epigenetic/post-transcriptional/post-translational target for cancer treatment, and identify the successes and drawbacks of this treatment.
(Refer to Tsai and Baylin 2011)
2. Currently, there are two main hypotheses to explain why cancer cells exhibit the Warburg effect (also known as aerobic glycolysis). Choose one of these viewpoints and provide supportive evidence for your argument (these viewpoints outlined in the introduction of the paper below).
(Refer to Kim et al. 2009)
3. Table 2.9 (Weinberg) documents examples of epidemiological correlations between cancer incidence and environmental/lifestyle factors that have no apparent causal relationship. Choose one of these relationships to explore in more detail and provide evidence supporting or refuting a causal relationship between the lifestyle/dietary factor/medical condition and the risk of a particular type of cancer.
(Refer to Greenwald and Dunn 2009)
4. Don't like these questions? Write your own! (but please stay on topic) Your original question should address at least one of the articles from the additional reading list.
- Discussion Board grading rubrics are available(please see "Rubrics" in the Assessment folder).
- Additional guidelinescan be found in"Expectations on Writing in Online Courses"
Our goal is to generate some thoughtful and insightful dialog about the issues at hand. Your timely participation in this dialog is crucial to the success of the Discussion and to your successful completion of this course.
Discussion Board Assignments will be posted within each Learning Unit module