Antigens and natural antibodies of ABO blood groups:
Iso antibodies:
The meaning of Iso is belonging to the same species. Isoantibody is an antibody generated through one individual that reacts with the antigen of another individual of similar species. Antibody – A and Antibody – B are known as Iso antibodies.
Isoantigens:
An antigen of an individual that is able of eliciting an immune response in individuals of similar species who are genetically dissimilar and who do not possess that antigen is termed as isoantigen.
Natural antibodies:
Human forms antibodies in opposition to the blood group antigens they do not express. These antibodies are called naturally taking place antibodies/isoagglutinins. It might be of IgM, IgG or IgA. Antibody production begins at 3 months of age, arrives at its highest level during adult and decreases with advancing age. Generally, Antibody A titers are higher than Antibody-B.
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