Change in primary-secondary-tertiary structure of protein
Is it predicted that a change in the primary, secondary or in the tertiary structure of a protein will generate more functional results?
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Any modification of the protein structure is relevant when it modifies its biological activity. Modifications in the primary protein structure are more vital since they are modifications in the composition of molecule and this composition finds out all other structures of protein.
In sickle cell anemia, a genetic disease, there is replacement of one amino acid by other in one of the four polypeptide chains of hemoglobin. In this situation are all structural levels of the protein altered?
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