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Why do you think lesley felt the affects of the medication

Lesley was prescribed pain medication for her recent surgery and was instructed to take one pain pill a day. On day 10 Lesley felt intense pain after taking her medication so she decided to take an additional dose. After doing this Lesley pain slowly went away. Why do you think Lesley felt the affects of the medication after taking two pills versus the one she had been taking 10 days prior?

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