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If cells synthesizing glucose from lactate are exposed to

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(1) If cells synthesizing glucose from lactate are exposed to CO₂ labeled with ¹⁴C, what will be the distribution of label in the newly synthesized glucose?

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(2) Explain the effects of each of the following on gluconeogenesis and glycolysis in a liver cell:

a. Increasing the concentration of AMP

b. Decreasing the concentration of acetyl-CoA
c. Increasing the concentration of F 2, 6 BP

d. Phosphorylation of PFK-2

e. Phosphorylation of fructose 2,6-bisphosphatase

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