Dogs are extremely susceptible to poisoning by theobromine, Biology

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Dogs are extremely susceptible to poisoning by theobromine

Dogs are extremely susceptible to poisoning by theobromine from chocolate, but only extreme doses complicate humans. Below are the oral LD50s:

LD50 half life

Dog 300 mg/kg 17 hr

Human 1200 mg/kg 2 hr

Given the data, provide a plausible explanation of why the half-life and LD50 are so different for this toxicant (limit 3-4 sentences)

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