Describe the mechanism of histone modification.
We will deliberate the mechanisms and effects of histone alterations on gene expression and techniques on how to study them.
Learning Objectives
At the end of this segment, you will can
• deliberate the impact of histone acetylation, phosphorylation, and methylation on gene transcription
• name inhibitors of histone de-acetylation and methylation
• define techniques that can be used to detect histone modifications
• define the goals of the worldwide effort to identify the human epigenome
Discussion Assignment
American Association for Cancer Research Human Epigenome Task Force. Network of Excellence, European Union, Scientific Advisory Board, Moving AHEAD with an International Human Epigenome Project.
If you were to be a donor to the AHEAD project, label what your project would entail. Otherwise, how would you smear knowledge obtained from the AHEAD project to your individual research project?