Though immune system is protective, the identical immunologic mechanisms which defend the host might sometimes outcome in severe harm to tissues and cause death seldom. The injurious reaction as the outcome of antigen and the products of immune response outcomes in hypersensitivity. This kind of immune response might be immediate or delayed.
For hypersensitivity reaction to take place the individual must have initial contact with the allergen [i.e., antigen] that leads to sensitizing B or T cells. This is termed as sensitizing or priming dosage. Subsequent contact with allergen causes manifestations of hypersensitivity. This is termed as shocking dosage.
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