--%>
Assignment Help - homework help

Sickle cell anemia-hereditary disease-polypeptide chains

In the sickle cell anemia, hereditary disease, there is swap of one amino acid through another in one of the four polypeptide chains of hemoglobin. In this situation are all of the structural levels of protein modified?

E

Expert

Verified

In the sickle cell disease there is an alteration in primary protein structure of one of polypeptide chains which form hemoglobin: amino acid glutamic acid is substituted through the amino acid valine in β chain. The spatial conformation of molecule additionally is also influenced and modified through this primary ‘mistake’ and the modification as well makes a different (sickle) shape to red blood cells. Modified, or sickled, red blood cells sometimes cumulative and obstruct peripheral circulation causing tissue hypoxia as well as pain crisis typical of sickle cell anemia.

   Related Questions in Biology

  • Q : What is proteinuria What do you mean by

    What do you mean by the term proteinuria? Why proteinuria is considered as the sign of glomerular renal injury?

    		•
  • Q : What are datasets Datasets : Datasets

    Datasets: Datasets are sequential files (that is, processed on application server) are termed as datasets. They are employed for file handling in SAP.

    		•
  • Q : Vertebrate and invertebrates nervous

    Specify some of the main differences of vertebrate nervous systems comparing to the invertebrates?

    		•
  • Q : How arthropods grow How arthropods grow?

    How arthropods grow?

    		•
  • Q : Impact of Environment on Operational

    It is an imperative that when formulating Operational plans the environments in which the business operates in are considered, identify the environments and the tools used to analyze the impact of environment each on planning.

    		•
  • Q : Explain endocrine glands Explain the

    Explain the endocrine glands which regulate sexual action in males? What are the involved hormones and how does it regulation work?

    		•
  • Q : Significance of primary structure of a

    Explain the primary structure of a protein? What is the significance of primary structure?

    		•
  • Q : Six Specific Trends of Organizational

    1) Declining productivity and the Japanese threat: the challenge is to reverse declining trends: ensuring better interplay between management approaches and techniques, and employees. 2) Revolution in middle management:  A big cut in the middle management cadre; restructuring and red

    		•
  • Q : Question related to influence of tax on

    A sales tax of $1 per unit of output is located on one firm whose product sells for $5 in a competitive industry. How will this tax influence the cost curves for the firm?Along with the imposition of a $1 tax on a single firm, all its cost curve

    		•
  • Q : Window phase of infection What is the

    What is the window phase of infection? How is this concept significant for the test of HIV infection in the blood banks?

    		•