Discussion Post: Biochemistry
• Why are high density lipoproteins (HDLs) considered the "good cholesterol"? In your answer explain specifically what HDLs do that cause it to be considered the "good cholesterol".
• Why are low density lipoproteins (LDLs) considered the "bad cholesterol"? In your answer explain specifically what LDLs do that cause it to be considered the "bad cholesterol".
• What is the role of the phospholipid monolayer at the outer surface of lipoprotein particles?
• Why are cholesterol, cholesteryl esters, and triglycerides preferentially contained inside lipoprotein particles? (Question 2 of case study)
• What are the two sources of cholesterol in the human body?
• What is a "committed step" in a biochemical pathway? (Question 3 of case study)
• Looking at Figure 4 of case study (the reaction pathway from acetyl-CoA), which enzyme is likely to be the target of the statin mevastatin? (Question 6 of case study)
• What are four ways that HDL levels can be increased in the body?
• What type of inhibitor (non-competitive OR competitive) are statins with respect to HMG-CoA reductase enzyme activity? Explain why.
• How were cholesterol-lowering statin drugs first discovered?
The response must include a reference list. Using Times New Roman 12 pnt font, double-space, one-inch margins, and APA style of writing and citations.