What greatest challenge to developing vaccine to malaria is, Biology

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What greatest challenge to developing vaccine to malaria is

Problem

A. If the host immune response has developed many mechanisms to neutralize and remove pathogen bacteria and in turn, pathogenic bacteria have developed mechanisms to alter and evade the host immune response, in what ways can we stop this cycle and fight them off completely?

B. What are your thoughts on what the greatest challenge to developing a vaccine to malaria is? What stage of P. falciparum's life cycle would be the best target and why?

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