What are all possibilities of genotypes and phenotypes formed in the combination of alleles responsible for the production of factor VIII?
Considering the alleles X and Xh, where Xh represents the allele that conditions hemophilia A, in women the possible genotypes are XX, XXh and XhXh. In men the possible genotypes are XY and XhY. Concerning the phenotypes, factor VIII is produced in every individual with at least one nonaffected X chromosome. Therefore the women XX and X Xh and the men XY are normal. Only women XhXh and men XhY have the disease.