A small fraction of loci in the genome do not have perfect Mendelian segregation. They undergo meiotic drive, such that when a heterozygote produces gametes, they are not in the expected 50/50 ratio. Suppose a population at present has genotype frequencies of 0.49 AA, 0.42 Aa, and 0.09 aa. Suppose the locus under consideration has meiotic drive such that Aa heterozygotes produce 0.2 A gametes and 0.8 a gametes.
(a) What will the change in allele frequency be from the present generation to the next?
(b) Assuming random mating, what will the genotype frequencies be in the next generation?
(c) What are the long-term consequences of meiotic drive on variation at this locus?