Pilocarpine across the corneal membrane of the eye

Question

Assignment:

Transport of pilocarpine across the corneal membrane

Obtain the delta H and delta S in the example 3 - 14 on page 71 of Martin's Physical Pharmacy. A set of data (log Ka v. 1/T x 10^3) is plotted and the linear form of the van't hoff equation should be used to calculate delta H and delta S. The equation in this form is:
ln K = -(delta H/R)1/T + delta S/R or y = mx + b where: delta H/R = m and delta S/R = b.

Question-1

In the study of the transport of pilocarpine across the corneal membrane of the eye, Mitra and Mikkelson presented a van't Hoff

Problem        
    1/K'    pH
    0.2315    3.3
    0.2801    3.4
    0.4    3.6
    0.6993    3.9
    1.0526    4.11

2 Anhydrous
ln/X 1/T
-1.1394 0.1
-0.9676 0.04
-0.6162 0.027

Did not convert to mole fraction first!

2 Dihydrate
ln/X 1/T

Question-2

Cg (g/L) π / cg (l-atm g^-1)
1.25 7.76E-03
2.5 7.90E-03
3.75 8.03E-03
5 8.16E-03

Question-3

	C	K	1/T	log X	X
Ibuprofen	75	348.15	0.002872	2.579784	380
Alclofenac	92	365.15	0.002739	2.875061	750
Ketoprofen	94	367.15	0.002724	2.845098	700
Fenclofenac	134	407.15	0.002456	2.146128	140
Diclofenac	155	428.15	0.002336	0.90309	8
Indomethicin	155	428.15	0.002336	-1	0.1
Naproxen	155	428.15	0.002336	1.845098	70
Sulidac	182	455.15	0.002197	1	10
Fenbuprofen	185	458.15	0.002183	0.69897	5
Indoprofen	213	486.15	0.002057	1.176091	15

75	348.15	0.002872	2.579784	380
92	365.15	0.002739	2.875061	750
94	367.15	0.002724	2.845098	700
134	407.15	0.002456	2.146128	140
110	383.15	0.00261	2.376577	238
155	428.15	0.002336	1.845098	70	?????
155	428.15	0.002336	0.90309	8
155	428.15	0.002336	-1	0.1
182	455.15	0.002197	1	10
185	458.15	0.002183	0.69897	5
213	486.15	0.002057	1.176091	15

75	348.15	0.002872	2.579784	380	206	2.313867
92	365.15	0.002739	2.875061	750	226	2.354108
94	367.15	0.002724	2.845098	700	254	2.404834
134	407.15	0.002456	2.146128	140	297	2.472756
110	383.15	0.00261	2.477121	300	305	2.4843

Alpha-Methyls	C	K	1/T	log X	X
Indomethicin	155	428.15	0.002336	-1	0.1
Fenbuprofen	185	458.15	0.002183	0.69897	5
Indoprofen	213	486.15	0.002057	1.176091	15
Ketoprofen	94	367.15	0.002724	2.845098	700
Ibuprofen	75	348.15	0.002872	2.579784	380
Naproxen	155	428.15	0.002336	1.845098	70

Question-4

    1/T x 10³    log Ka   
    3.47    -7.13   
    3.41    -6.97   
    3.35    -6.9   
    3.3    -6.8   
    3.24    -6.67   
    3.19    -6.53   
    3.14    -6.4   

In the study of the transport of pilocarpine across the corneal membrane of the eye, Mitra and Mikkelson presented a van't Hoff
plot of the log of the ionization constant, log Ka, of pilocarpine versus the recipocal of the absolute temperature, 1/T. Using the data in
Table 1 above, regress log Ka versus 1/T. With reference to the van't Hoff equation below :

                                                    ln K = - (delta H^o/R)1/T + deltaS^o/R

obtain the standard heat (enthalpy), delta H, of inoization for pilocarpine and the standard entropy for the ionization
process.