1) Overexpression mutations can be oncogenic because the oncogene is
a) translocated next to an active regulatory sequence
b) amplified
c) altered in a regulatory sequence
d) all of the above
e) none of the above
2) Translocation of a gene can produce a fusion product with uncontrolled protein kinase activity. An example of this type offusion protein is
a) Tel/PDGFR
b) Myc/Max
c) Fos/Jun
d) ErbB/Ras
e) Raf/MEK
3) Cancer cells often develop the ability to avoid apoptosisby
a) surviving in the absence of growth factors
b) inactivationg p53
c) losing the ability to detect Dna damage
d) all of the above
e) none of the above
4) The function of tumor suppressor protein p53 is to
a) activate the synthesis of p21, a Cdk inhibitor
b) induce apoptosis
c) phosphorylate cyclin-dependent kinase on an inhibitorysite
d) all of the above
e) boh a and b
5) Angiogenesis inhibitors are useful for inhibiting tumorgrowth because
a) blood vessel enothelial cell tumors are common
b) inhibiting angiogenesis prevents growing tumors
6) Drugs that inhibit oncogene function generally will
a) inhibit division of tumor cells only
b) kill tumor cells only
c) kill tumor cells as well as normal cells
d) inhibit cell division of both tumor cells and normalcells
e) induce cell differentiation.