explain the toxicity of nicotinic acidalthough, Biology

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explain the toxicity of nicotinic acidalthough

Explain the Toxicity of nicotinic acid?

Although therapeutically useful in lowering serum cholesterol, administration of chronic high oral doses of nicotinic acid can lead to hepatotoxicity, as well as, dermatologic manifestations. An upper limit (UL) of 35 mg /day as proposed by the United States Food and Nutrition Board has been adopted by the FAO/WHO 2004 Consultation on Vitamin and Mineral Requirements.

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