Problem
Jamovi tutorial- Dependent/Paired T test
1) Enter or import data
2) Select T-Tests
3) Select Paired T-Test
4) Select your Dependent Variables and then click the arrow
a) Be sure to select your "pre" variable first and "post" second
5) Select Descriptives to also calculate those if you don't have them already for your sample
6) Select Descriptives Plots if you also wish to plot the Pre/Post samples
For the following questions, use Dataset 3.1 shown below
I. This experiment sought to look at a within subjects/ repeated design to test the effect of administration of the drug "ZIP" on cultured neurons. In this case measurements of sEPSCs were obtained both before (baseline) and after administration (post ZIP) of the drug.
i) Using a repeated/ paired t-test, what is the t value and p value (two tailed) of the paired samples' sEPSCs Frequencies?
ii) Did administration of ZIP significantly alter the sEPSC Frequencies of these cells? (assume 2 tailed test at α=0.05) Explain using p-value, means, and standard deviations/ errors of the mean.
II i) Using a repeated/ paired t-test, what is the t value and p value (two tailed) of the paired samples' sEPSCs Amplitudes?
ii) Did administration of ZIP significantly alter the sEPSC Amplitudes of these cells? (assume 2 tailed test at α=0.05) Explain using p-value, means, and standard deviations/ errors of the mean.
III. Explain the findings of this study in laymen's terms. Where these cells significantly different from the population of cultured neurons in terms of RMP and Baseline sEPSC frequency? Did the drug "ZIP" effect the cells sEPSC properties? If so how and what direction?
|
Cell
|
Baseline RMP (mV)
|
Baseline sEPSC Frequency (hz)
|
Baseline sEPSC Amplitude (pA)
|
sEPSC post ZIP Frequency
|
sEPSC post ZIP Amplitude
|
Previous population RMP (mV)
|
Previous population Baseline Frequency
|
|
1
|
-70
|
1.2
|
10
|
1
|
15
|
-72.5
|
1
|
|
|
|
|
2
|
-70
|
1
|
9
|
1.2
|
16
|
|
|
|
|
|
|
3
|
-69.9
|
0.9
|
11
|
1
|
17
|
|
|
|
|
|
|
4
|
-70.1
|
1
|
12
|
1
|
14
|
|
|
|
|
|
|
5
|
-70
|
1
|
8
|
0.9
|
13
|
|
|
|
|
|
|
6
|
-70.2
|
1.2
|
10
|
1
|
15
|
|
|
|
|
|
|
7
|
-69.8
|
1
|
11
|
0.9
|
15
|
|
|
|
|
|
|
8
|
-69.9
|
0.9
|
10
|
1
|
15
|
|
|
|
|
|
|
9
|
-70.1
|
1
|
9
|
1
|
16
|
|
|
|
|
|
|
10
|
-70
|
1
|
10
|
1.2
|
17
|
|
|
|
|
|
|
11
|
-69.9
|
0.8
|
11
|
1
|
14
|
|
|
|
|
|
|
12
|
-70.1
|
1.1
|
10
|
0.9
|
15
|
|
|
|
|
|
|
13
|
-70
|
1.4
|
9
|
1
|
16
|
|
|
|
|
|
|
14
|
-70
|
0.7
|
10
|
1
|
14
|
|
|
|
|
|
|
15
|
-70.2
|
0.9
|
9
|
0.99
|
15
|
|
|
|
|
|
|
16
|
-69.8
|
1
|
11
|
0.9
|
15
|
|
|
|
|
|
|
17
|
-70
|
1
|
12
|
0.85
|
15
|
|
|
|
|
|
|
18
|
-70.2
|
1.2
|
8
|
1.1
|
16
|
|
|
|
|
|
|
19
|
-69.8
|
1.24
|
10
|
1.32
|
17
|
|
|
|
|
|
|
20
|
-70
|
0.99
|
11
|
0.7
|
14
|
|
|
|
|
|
|
21
|
-70.3
|
0.9
|
10
|
0.9
|
15
|
|
|
|
|
|
|
22
|
-70.1
|
0.85
|
9
|
1
|
16
|
|
|
|
|
|
|
23
|
-69.7
|
1.1
|
10
|
1
|
14
|
|
|
|
|
|
|
24
|
-69.9
|
1.32
|
11
|
1.2
|
15
|
|
|
|
|
|
|
25
|
-70
|
0.93
|
10
|
1.24
|
16
|
|
|
|
|
|
|
26
|
-70.1
|
0.95
|
9
|
0.99
|
17
|
|
|
|
|
|
|
27
|
-69.9
|
0.89
|
11
|
1.05
|
14
|
|
|
|
|
|
|
28
|
-70
|
1.1
|
12
|
1.03
|
15
|
|
|
|
|
|
|
29
|
-70.1
|
1.05
|
8
|
1
|
16
|
|
|
|
|
|
|
30
|
-69.9
|
1.03
|
10
|
1
|
14
|
|
|
|
|
|
|
31
|
-70
|
1
|
11
|
0.95
|
15
|
|
|
|
|
|
|
32
|
-70.1
|
1
|
10
|
0.89
|
16
|
|
|
|
|
|
|
33
|
-70.4
|
0.95
|
9
|
1.1
|
17
|
|
|
|
|
|
|
34
|
-69.8
|
0.89
|
10
|
1.05
|
14
|
|
|
|
|
|
|
35
|
-70
|
1.1
|
11
|
1.05
|
15
|
|
|
|
|
|
|
36
|
-70
|
1.05
|
10
|
1.03
|
16
|
|
|
|
|
|
|
37
|
-70
|
1.03
|
9
|
1
|
14
|
|
|
|
|
|
|
38
|
-69.9
|
1
|
11
|
1
|
15
|
|
|
|
|
|
|
39
|
-70.1
|
1
|
12
|
0.95
|
15
|
|
|
|
|
|
|
40
|
-70
|
1.1
|
8
|
0.89
|
15
|
|
|
|
|
|
|
41
|
-69.9
|
1.05
|
10
|
1.1
|
15
|
|
|
|
|
|
|
42
|
-70.1
|
1.03
|
11
|
1.05
|
14
|
|
|
|
|
|
|
43
|
-70
|
1
|
10
|
1.05
|
16
|
|
|
|
|
|
|
44
|
-69.9
|
1.3
|
9
|
1.03
|
15
|
|
|
|
|
|
|
45
|
-70.1
|
1.1
|
10
|
1
|
16
|
|
|
|
|
|
|
47
|
-70
|
0.9
|
11
|
1.3
|
14
|
|
|
|
|
|
|
48
|
-70
|
0.8
|
10
|
1.1
|
15
|
|
|
|
|
|
|
48
|
-70
|
0.9
|
9
|
0.9
|
16
|
|
|
|
|
|
|
49
|
-70
|
1.1
|
10
|
0.8
|
15
|
|
|
|
|
|
|
50
|
-69.9
|
0.9
|
10
|
1
|
15
|
|
|
|
|
|