Biochemistry Assignment
Competency 208.5.2: Amino Acids and Peptide Bonds, Protein Structure - The graduate can construct models of the structure and function of amino acids and peptide bonds, predict ionization of an amino acid, and demonstrate peptide bond breaking; and demonstrate how protein structure affects susceptibility or resistance to disease.
Competency 208.5.3: Myoglobin and Hemoglobin - The graduate constructs models of various states of hemoglobin, demonstrates how changes in the usual configuration of hemoglobin can lead to molecular disease, and distinguishes between the chemical structure and function of hemoglobin and myoglobin.
Competency 208.5.4: Enzymology and Catalytic Mechanism - The graduate constructs models of enzymes, demonstrates how enzymes act as a catalyst in a reaction and factors that influence this reaction, and solves enzyme and catalysis problems.
Introduction:
Proteins are essential to life, and the exact way a protein is made will determine its function. In this assessment, you will write an analysis of how protein structure plays a role in normal protein function, how changes in protein structure can lead to disease, and how enzyme structure and function can be exploited for drug treatment. To complete parts B and C of this task, you must refer to the protein, pathway, and enzyme assigned to you using the attached "ZZP1 Tasks Spreadsheet."
You may refer to the attached "Protein Structure through Genetic Diseases" document as an additional resource to assist you with this task.
You will work through the scenario to respond to part A only.
Scenario
Some researchers are working to find a treatment for sickle cell anemia. They have identified a drug that prevents the subunits of hemoglobin from associating with one another, thereby keeping the hemoglobin proteins as monomers and preventing filament formation. You are asked to make a recommendation about the adoption of this drug as a treatment for Part A.
Requirements:
Your submission must be your original work. No more than a combined total of 30% of the submission and no more than a 10% match to any one individual source can be directly quoted or closely paraphrased from sources, even if cited correctly. Use the Turnitin Originality Report available in Taskstream as a guide for this measure of originality.
You must use the rubric to direct the creation of your submission because it provides detailed criteria that will be used to evaluate your work. Each requirement below may be evaluated by more than one rubric aspect. The rubric aspect titles may contain hyperlinks to relevant portions of the course.
Note: Download the attached "ZZP1 Tasks Spreadsheet", then open the file. When the file "ZZP1 Tasks Spreadsheet" opens, enter your name and student ID as they appear in Taskstream into the appropriate boxes. When you do this, the components you need to complete parts B and C of this task will populate in the worksheet. Images of the pathway for part C are in the "ZZP1 Task 2 Pathways" file. If the attached template does not open or is missing information, please contact Ecare [email protected] for assistance with opening the file. WGU has partnered with Microsoft to offer Office for free for our students. Please click on this link and enter your WGU student email (use your @my.wgu.edu account) to find out eligibility: https://office.microsoft.com/en-us/office-in-education-FX104367920.aspx.
Note: Diagrams may be used to support your response.
Note: Use the attached "ZZP1 Task Spreadsheet" document to identify your assigned protein, pathway, and enzyme to complete parts B and C.
A. Discuss whether you would recommend the drug in the scenario as a treatment for sickle cell anemia.
B. Demonstrate how a change in the protein structure can lead to disease by doing the following:
1. Describe the normal function and importance of the assigned protein.
2. Discuss how a change in the assigned protein structure affects the protein's function and leads to the disease state.
C. Analyze how an assigned enzyme acts in the assigned pathway, including how a hypothetical drug could impact the assigned pathway, by doing the following:
1. Describe the reaction catalyzed by the assigned enzyme.
2. Explain how feedback inhibition of the assigned enzyme would affect each step in the assigned pathway.
3. Explain how a hypothetical drug can be used to increase the amount of the assigned molecule in the assigned pathway.
D. Acknowledge sources, using in-text citations and references, for content that is quoted, paraphrased, or summarized.
Attachment:- Linear_Pathways.pdf