Question: Which of the following best describes the pathogenesis of heparin induced thrombocytopenia? Systemic deposition of platelet thrombi with abundance of von Willebrand factor (vWF) due to autoimmune destruction of ADAMTS13 Immunoglobulin G antibodies against platelet membrane glycoproteins IIb-IIIa or Ib-IX, causing platelet destruction Massive systemic intravascular activation of coagulation, leading to widespread deposition of fibrin in the circulation Infiltration and replacement of normal marrow space by nonhematopoietic or abnormal cells Binding of antibodies to complexes of heparin and platelet factor 4, causing platelet activation and promoting a prothrombotic state