Problem:
Severe combined immunodeficiency syndrome (SCID) is characterized by the lack of an immune response to infectious diseases. Many SCID patients have a deficiency of adenosine deaminase (see figure in the appendix), which catalyzes the deamination of adenosine to produce inosine. The enzyme deficiency increases dATP levels but decreases the levels of other deoxynucleotides, thereby inhibiting DNA replication and cell division in certain rapidly dividing cells.
Required:
Question: Explain how an adenosine deaminase deficiency affects the levels of deoxynucleotides.
Could someone explain this to me?