Acidity between p-methoxybenzoic and m-methoxybenzoic acid


Assignment:

Q1.

2204_Iupac.JPG

Q2. Even through the para position is one carbon father from the coarboxyl group than the meta position, p-cyanobenzoic acid is more acidic than m-cyanobenzoic acid. Explain the differences in acidity between p-cyanobenzoic acid and m-cyanobenzoic acid.

Q3. Explain the differences in acidity between p-methoxybenzoic and m-methoxybenzoic acid.

Q4. Write the complete stepwise mechanism for the basic hydrolysis of acetamide, shown below. Show all electron flow with arrows and draw all intermediate structures.

697_Hydrolysis of acetamide.JPG

Q5. Consider structures answer questions. Indicate acidic hydrogen molecules. Rank molecules order increasing acidity (least acidic).

2483_Acidic hydrogen molecules.JPG


Q6.    What order decreasing reactivity nucleophilic acyl substitutions carboxylic acid derivatives? (most relative first)

A.

1795_nucleophilic.JPG

B.

2475_substitutions.JPG

Provide complete and step by step solution for the question and show calculations and use formulas.

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Chemistry: Acidity between p-methoxybenzoic and m-methoxybenzoic acid
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