Problem- A chemist at a pharmaceutical company is measuring equilibrium constants for reactions in which drug candidate molecules bind to a protein involved in cancer. The drug molecules bind the protein in a 1:1 ratio to form a drug-protein complex. The protein concentration in aqueous solution at 25 ?C is 1.90×10^-6M . Drug A is introduced into the protein solution at an initial concentration of 2.00×10^-6M. Drug B is introduced into a separate, identical protein solution at an initial concentration of 2.00×10^-6M. At equilibrium, the drug A-protein solution has an A-protein complex concentration of 1.00×10^-6M, and the drug B solution has a B-protein complex concentration of 1.40×10^-6M.
Part A
Calculate the Kc value for the A-protein binding reaction.
Part B
Calculate the Kc value for the B-protein binding reaction.
Part C
Assuming that the drug that binds more strongly will be more effective, which drug is the better choice for further research?
Drug A is the better choice for further research.
Drug B is the better choice for further research.
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