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Functionality of denatured enzyme

What occurs to a denatured enzyme about its functionality? How can that answer be described with the aid of the lock and key model?

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According to the lock and key model the enzyme functionality based completely on the integrity of an activation center, a molecular area with particular spatial characteristics. Subsequent to the denaturation the spatial conformation of the protein is altered, the activation center is ruined and the enzyme loses its catalytic activity.

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