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Foreignness of a molecule

Briefly, explain regarding the foreignness of a molecule, that makes a substance antigenic?

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To be antigenic macro-molecules should come from foreign source. The Antigens from associated species are less antigenic as compared to unrelated species. More is the distance antigen source the good is the antigenesity.

Example: Plant proteins are excellent antigens in animals, whereas duck serum proteins are not excellent antigens for chick.   

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